SARSUAG EXPERIENCE AND EXPERTISE

  • Antibody development : Monoclonal and polyclonal antibodies,Cascade immunization.
  • Antibody purification : Anti-drug antibodies, neutralizing antibodies, analogue specific antibodies, protein A, G.
  • Antibody conjugation Biotin,HRP and FITC.
  • Antibody HCP characterization : Antibody isotype, anti-HCP antibody and HCP antigen characterization using 1D,2D western blot.
  • Cell based and non-cell based Nab assay development : Functional enzyme inhibitor based non-cell based assay andradiolabeledand unlabeled functional metabolic assay.
  • Immunoassay development/qualification :Specific, sensitive serum based-PK, Immunogenicity (3 tier approach- ADA screening, confirmatory, and neutralizing antibodies assay titration analysis), Commercial kit optimization, antibody pairing.
  • Immunoassay non-serum based CMC assay development :HCP assay (E.coli, Pichia and CHO) and Protein A .